Below is a list of papers published by David O’Connor
and, since 2005, the O’Connor Laboratory.
*Denotes article co-authors
Bimber, B., and D. H. O'Connor.
2008. KIRigami: the case for studying NK cell
receptors in SIV+ macaques. Immunol Res 40:
235-243.
Review article describing killer immunoglobulin receptor
genetics in macaques.
Florese, R. H., R. W. Wiseman, D. Venzon,
J. A. Karl, T. Demberg, K. Larsen, L. Flanary, V. S.
Kalyanaraman, R. Pal, F. Titti, L. J. Patterson, M. J.
Heath, D. H. O'Connor, A. Cafaro, B. Ensoli,
and M. Robert-Guroff. 2008. Comparative study of Tat
vaccine regimens in Mauritian cynomolgus and Indian
rhesus macaques: Influence of Mauritian MHC haplotypes
on susceptibility/resistance to SHIV(89.6P) infection.
Vaccine
Describes associations between MHC genetics in Mauritian
macaques and SIV susceptibility.
Wiseman, R. W., and D. H. O'Connor.
2007. Major Histocompatibility Complex-Defined
Macaques in Transplantation Research. Transplantation
Reviews 21: 17-26.
Review describing recent advances in MHC genetics in
macaques, with an emhpasis on applications to organ
transplantation research.
O'connor, S. L., A. J. Blasky, C. J.
Pendley, E. A. Becker, R. W. Wiseman, J. A. Karl, A.
L. Hughes, and D. H. O'connor. 2007.
Comprehensive characterization of MHC class II
haplotypes in Mauritian cynomolgus macaques.
Immunogenetics 59: 449-462.
Complete description of MHC class II genetics on Mauritian
macaques.
Wiseman RW*, Wojcechowskyj JA*, Greene JM,
Blasky AJ, Gopon T, Soma T, Friedrich TC, O'Connor SL,
O'Connor DH (2007) Simian Immunodeficiency
Virus SIVmac239 Infection of Major Histocompatibility
Complex-Identical Cynomolgus Macaques from Mauritius.
J Virol 81: 349-361.
Paper describing MHC class I haplotypes in Mauritian
macaques. Also demonstred that Mauritian macaques are
susceptible to infection with highly pathogenic SIVmac239.
Wojcechowskyj JA, Yant LJ, Wiseman RW,
O'connor SL, O'Connor DH (2007) Control of
Simian Immunodeficiency Virus SIVmac239 Is Not
Predicted by Inheritance of Mamu-B*17-Containing
Haplotypes. J Virol 81: 406-410.
First attempt to associate entire MHC haplotypes with
control of SIV.
Wilson, N. A., J. Reed, G. S. Napoe, S.
Piaskowski, A. Szymanski, J. Furlott, E. J. Gonzalez,
L. J. Yant, N. J. Maness, G. E. May, T. Soma, M. R.
Reynolds, E. Rakasz, R. Rudersdorf, A. B. McDermott,
D. H. O'connor, T. C. Friedrich, D. B. Allison,
A. Patki, L. J. Picker, D. R. Burton, J. Lin, L.
Huang, D. Patel, G. Heindecker, J. Fan, M. Citron, M.
Horton, F. Wang, X. Liang, J. W. Shiver, D. R.
Casimiro, and D. I. Watkins. 2006. Vaccine-Induced
Cellular Immune Responses Reduce Plasma Viral
Concentrations after Repeated Low-Dose Challenge with
Pathogenic Simian Immunodeficiency Virus SIVmac239. J
Virol 80:5875.
Paper describing reduction of SIV viral loads by cellular
immune responses alone.
Yant, L. J., T. C. Friedrich, R. C.
Johnson, G. E. May, N. J. Maness, A. M. Enz, J. D.
Lifson, D. H. O'connor, M. Carrington, and D.
I. Watkins. 2006. The High-Frequency Major
Histocompatibility Complex Class I Allele Mamu-B*17 Is
Associated with Control of Simian Immunodeficiency
Virus SIVmac239 Replication. J Virol 80:5074.
Identification of the association between the MHC class I
allele Mamu-B*17 and SIV control.
O'Connor, D. H., and D. R. Burton.
2006. Immune responses and HIV: a little order from
the chaos. J Exp Med 203:501.
Commentary on two articles describing HIV infection of
monozygotic twins.
McDermott, A. B., D. H. O'Connor, S.
Fuenger, S. Piaskowski, S. Martin, J. Loffredo, M.
Reynolds, J. Reed, J. Furlott, T. Jacoby, C. Riek, E.
Dodds, K. Krebs, M. E. Davies, W. A. Schleif, D. R.
Casimiro, J. W. Shiver, and D. I. Watkins. 2005.
Cytotoxic T-lymphocyte escape does not always explain
the transient control of simian immunodeficiency virus
SIVmac239 viremia in adenovirus-boosted and DNA-primed
Mamu-A*01-positive rhesus macaques. J Virol
79:15556.
Examination of cellular immune responses and viral escape
in animals receiving a recombinant adenovirus vaccine for
SIV.
Casimiro, D. R., F. Wang, W. A. Schleif, X.
Liang, Z. Q. Zhang, T. W. Tobery, M. E. Davies, A. B.
McDermott, D. H. O'Connor, A. Fridman, A.
Bagchi, L. G. Tussey, A. J. Bett, A. C. Finnefrock, T.
M. Fu, A. Tang, K. A. Wilson, M. Chen, H. C. Perry, G.
J. Heidecker, D. C. Freed, A. Carella, K. S. Punt, K.
J. Sykes, L. Huang, V. I. Ausensi, M. Bachinsky, U.
Sadasivan-Nair, D. I. Watkins, E. A. Emini, and J. W.
Shiver. 2005. Attenuation of simian immunodeficiency
virus SIVmac239 infection by prophylactic immunization
with dna and recombinant adenoviral vaccine vectors
expressing Gag. J Virol 79:15547.
Performance of a recombinant adenovirus vaccine for SIV.
Hughes, A. L., H. Piontkivska, K. C. Krebs,
D. H. O'connor, and D. I. Watkins. 2005.
Within-host evolution of CD8+-TL epitopes encoded by
overlapping and non-overlapping reading frames of
simian immunodeficiency virus. Bioinformatics 21 Suppl
3:iii39.
Viral escape in HIV/SIV sometimes happens in regions that
encode two different proteins. Changes that modify the
amino acid of one protein often are silent with respect to
the other.
Krebs, K. C., Z. Jin, R. Rudersdorf, A. L.
Hughes, and D. H. O'connor. 2005. Unusually
high frequency MHC class I alleles in mauritian origin
cynomolgus macaques. J Immunol 175:5230.
First description of MHC class I genetics of Mauritian
macaques. Demonstrated that cynomolgus macaques from
different origins have non-overlapping MHC class I alleles.
Fernandez, C. S., I. Stratov, R. De Rose,
K. Walsh, C. J. Dale, M. Z. Smith, M. B. Agy, S. L.
Hu, K. Krebs, D. I. Watkins, D. H. O'connor, M.
P. Davenport, and S. J. Kent. 2005. Rapid viral escape
at an immunodominant simian-human immunodeficiency
virus cytotoxic T-lymphocyte epitope exacts a dramatic
fitness cost. J Virol 79:5721.
Defines the kinetics of SIV escape from cellular immune
responses in pig-tailed macaques.
Loffredo, J. T., J. Sidney, S. Piaskowski,
A. Szymanski, J. Furlott, R. Rudersdorf, J. Reed, B.
Peters, H. D. Hickman-Miller, W. Bardet, W. M.
Rehrauer, D. H. O'connor, N. A. Wilson, W. H.
Hildebrand, A. Sette, and D. I. Watkins. 2005. The
High Frequency Indian Rhesus Macaque MHC Class I
Molecule, Mamu-B*01, Does Not Appear to Be Involved in
CD8+ T Lymphocyte Responses to SIVmac239. J Immunol
175:5986.
Contrary to previous reports, we show that the rhesus
macaque MHC allele Mamu-B*01 does not present peptides to T
cells during SIV infection.
Smith, M. Z., C. J. Dale, R. De Rose, I.
Stratov, C. S. Fernandez, A. G. Brooks, J. Weinfurter,
K. Krebs, C. Riek, D. I. Watkins, D. H.
O'Connor, and S. J. Kent. 2005. Analysis of
pigtail macaque major histocompatibility complex class
I molecules presenting immunodominant simian
immunodeficiency virus epitopes. J Virol 79:684.
Description of SIV-specific T cell responses in pig-tailed
macaques.
Smith, M. Z., C. S. Fernandez, A. Chung, C.
J. Dale, R. De Rose, J. Lin, A. G. Brooks, K. C.
Krebs, D. I. Watkins, D. H. O'Connor, M. P.
Davenport, and S. J. Kent. 2005. The pigtail macaque
MHC class I allele Mane-A*10 presents an immundominant
SIV Gag epitope: identification, tetramer development
and implications of immune escape and reversion. J Med
Primatol 34:282.
First description of an SIV-specific T cell response in a
pig-tailed macaque.
O'Connor, D. H., A. B. McDermott, K.
C. Krebs, E. J. Dodds, J. E. Miller, E. J. Gonzalez,
T. J. Jacoby, L. Yant, H. Piontkivska, R. Pantophlet,
D. R. Burton, W. M. Rehrauer, N. Wilson, A. L. Hughes,
and D. I. Watkins. 2004. A dominant role for
CD8+-T-lymphocyte selection in simian immunodeficiency
virus sequence variation. J Virol 78:14012.
Manuscript that showed most viral variation outside of SIV
envelope is selected by cellular immune responses.
Loffredo, J. T., J. Sidney, C. Wojewoda, E.
Dodds, M. R. Reynolds, G. Napoe, B. R. Mothe, D. H.
O'Connor, N. A. Wilson, D. I. Watkins, and A.
Sette. 2004. Identification of seventeen new simian
immunodeficiency virus-derived CD8+ T cell epitopes
restricted by the high frequency molecule, Mamu-A*02,
and potential escape from CTL recognition. J Immunol
173:5064.
Defined SIV-specific T cells that recognize peptides bound
to the rhesus macaque allele Mamu-A*02.
Friedrich, T. C., A. B. McDermott, M. R.
Reynolds, S. Piaskowski, S. Fuenger, I. P. De Souza,
R. Rudersdorf, C. Cullen, L. J. Yant, L. Vojnov, J.
Stephany, S. Martin, D. H. O'Connor, N. Wilson,
and D. I. Watkins. 2004. Consequences of cytotoxic
T-lymphocyte escape: common escape mutations in simian
immunodeficiency virus are poorly recognized in naive
hosts. J Virol 78:10064.
Manuscript showing the viruses bearing CTL escape mutations
do not elicit cellular immune responses in macaques.
Matano, T., M. Kobayashi, H. Igarashi, A.
Takeda, H. Nakamura, M. Kano, C. Sugimoto, K. Mori, A.
Iida, T. Hirata, M. Hasegawa, T. Yuasa, M. Miyazawa,
Y. Takahashi, M. Yasunami, A. Kimura, D. H.
O'Connor, D. I. Watkins, and Y. Nagai. 2004.
Cytotoxic T lymphocyte-based control of simian
immunodeficiency virus replication in a preclinical
AIDS vaccine trial. J Exp Med 199:1709.
Macaque testing of a promising Sendia virus vector vaccine
for SIV.
Friedrich, T. C., E. J. Dodds, L. J. Yant,
L. Vojnov, R. Rudersdorf, C. Cullen, D. T. Evans, R.
C. Desrosiers, B. R. Mothe, J. Sidney, A. Sette, K.
Kunstman, S. Wolinsky, M. Piatak, J. Lifson, A. L.
Hughes, N. Wilson, D. H. O'Connor, and D. I.
Watkins. 2004. Reversion of CTL escape-variant
immunodeficiency viruses in vivo. Nat Med 10:275.
First manuscript to show that HIV/SIV escape from cellular
immune responses exacts a fitness cost to the virus.
Friedrich, T. C., C. A. Frye, L. J. Yant,
D. H. O'Connor, N. A. Kriewaldt, M. Benson, L.
Vojnov, E. J. Dodds, C. Cullen, R. Rudersdorf, A. L.
Hughes, N. Wilson, and D. I. Watkins. 2004.
Extraepitopic compensatory substitutions partially
restore fitness to simian immunodeficiency virus
variants that escape from an immunodominant
cytotoxic-T-lymphocyte response. J Virol 78:2581.
Description of cellular immune responses that select for
viral escape variants outside the actual epitope.
O'Connor, D. H.*, B. R. Mothe*, J.
T. Weinfurter*, S. Fuenger, W. M. Rehrauer, P. Jing,
R. R. Rudersdorf, M. E. Liebl, K. Krebs, J. Vasquez,
E. Dodds, J. Loffredo, S. Martin, A. B. McDermott, T.
M. Allen, C. Wang, G. G. Doxiadis, D. C. Montefiori,
A. Hughes, D. R. Burton, D. B. Allison, S. M.
Wolinsky, R. Bontrop, L. J. Picker, and D. I. Watkins.
2003. Major histocompatibility complex class I alleles
associated with slow simian immunodeficiency virus
disease progression bind epitopes recognized by
dominant acute-phase cytotoxic-T-lymphocyte responses.
J Virol 77:9029.
Definition of association of the rhesus macaque MHC class I
alleles Mamu-A*01 and Mamu-B*17 and control of SIV.
Altfeld, M., T. M. Allen, X. G. Yu, M. N.
Johnston, D. Agrawal, B. T. Korber, D. C. Montefiori,
D. H. O'Connor, B. T. Davis, P. K. Lee, E. L.
Maier, J. Harlow, P. J. Goulder, C. Brander, E. S.
Rosenberg, and B. D. Walker. 2002. HIV-1
superinfection despite broad CD8+ T-cell responses
containing replication of the primary virus. Nature
420:434.
One of the first definitive descriptions of HIV-1
superinfection.
O'Connor, D. H., T. M. Allen, and D.
I. Watkins. 2002. Cytotoxic T-lymphocyte escape
monitoring in simian immunodeficiency virus vaccine
challenge studies. DNA Cell Biol 21:659.
Review article describing immunologic escape in SIV+
macaques.
O'Connor, D. H.*, T. M. Allen*, T.
U. Vogel*, P. Jing, I. P. DeSouza, E. Dodds, E. J.
Dunphy, C. Melsaether, B. Mothe, H. Yamamoto, H.
Horton, N. Wilson, A. L. Hughes, and D. I. Watkins.
2002. Acute phase cytotoxic T lymphocyte escape is a
hallmark of simian immunodeficiency virus infection.
Nat Med 8:493.
Manuscript showing that escape from cellular immune
responses happens in the first weeks of all SIV, and
presumably HIV, infections.
Vogel, T. U., T. C. Friedrich, D. H.
O'Connor, W. Rehrauer, E. J. Dodds, H. Hickman, W.
Hildebrand, J. Sidney, A. Sette, A. Hughes, H. Horton,
K. Vielhuber, R. Rudersdorf, I. P. De Souza, M. R.
Reynolds, T. M. Allen, N. Wilson, and D. I. Watkins.
2002. Escape in one of two cytotoxic T-lymphocyte
epitopes bound by a high-frequency major
histocompatibility complex class I molecule,
Mamu-A*02: a paradigm for virus evolution and
persistence? J Virol 76:11623.
Shows that the rhesus macaque MHC class I allele Mamu-A*02
restricts two CTL responses that select for SIV escape
variants.
Vogel, T. U., H. Horton, D. H. Fuller, D.
K. Carter, K. Vielhuber, D. H. O'Connor, T.
Shipley, J. Fuller, G. Sutter, V. Erfle, N. Wilson, L.
J. Picker, and D. I. Watkins. 2002. Differences
between T cell epitopes recognized after immunization
and after infection. J Immunol 169:4511.
Comparison of cellular immune responses elicited by
vaccines and actual SIV infection.
Allen, T. M., B. R. Mothe, J. Sidney, P.
Jing, J. L. Dzuris, M. E. Liebl, T. U. Vogel, D. H.
O'Connor, X. Wang, M. C. Wussow, J. A. Thomson, J.
D. Altman, D. I. Watkins, and A. Sette. 2001. CD8(+)
lymphocytes from simian immunodeficiency
virus-infected rhesus macaques recognize 14 different
epitopes bound by the major histocompatibility complex
class I molecule mamu-A*01: implications for vaccine
design and testing. J Virol 75:738.
First use of peptide binding to systematically identify
SIV-specific T cell responses restricted by the Mamu-A*01
MHC class I alleles.
David O'Connor, Todd Allen and David
I. Watkins, Vaccination with CTL epitopes that escape:
an alternative approach to HIV vaccine development?,
Immunology Letters, Volume 79, Issues 1-2, 1 November
2001, Pages 77-84.
Review article describing CTL escape in SIV infection.
Allen, T. M.*, O'Connor, D. H.*, P.
Jing, J. L. Dzuris, B. R. Mothe, T. U. Vogel, E.
Dunphy, M. E. Liebl, C. Emerson, N. Wilson, K. J.
Kunstman, X. Wang, D. B. Allison, A. L. Hughes, R. C.
Desrosiers, J. D. Altman, S. M. Wolinsky, A. Sette,
and D. I. Watkins. 2000. Tat-specific cytotoxic T
lymphocytes select for SIV escape variants during
resolution of primary viraemia. Nature 407:386.
First description of CTL escape during the first weeks of
HIV/SIV infection. Here is a radio interview of Todd and
me discussing the implications of our 2000 Nature
paper on the dot.com-era internet radio station
eyada.com.
Evans, D. T., P. Jing, T. M. Allen,
O'Connor, D. H., H. Horton, J. E. Venham, M.
Piekarczyk, J. Dzuris, M. Dykhuzen, J. Mitchen, R. A.
Rudersdorf, C. D. Pauza, A. Sette, R. E. Bontrop, R.
DeMars, and D. I. Watkins. 2000. Definition of five
new simian immunodeficiency virus cytotoxic
T-lymphocyte epitopes and their restricting major
histocompatibility complex class I molecules: evidence
for an influence on disease progression. J Virol
74:7400.
Identification of 5 CTL responses in SIV-infected rhesus
macaques.
O'Connor, D. H., and D. I. Watkins.
1999. Houdini's box: towards an understanding of AIDS
virus escape from the cytotoxic T-lymphocyte response.
Immunogenetics 50:237.
Review of escape from cellular immune responses in HIV/SIV
infections.
Evans, D. T.*, D. H. O'Connor*, P.
Jing, J. L. Dzuris, J. Sidney, J. da Silva, T. M.
Allen, H. Horton, J. E. Venham, R. A. Rudersdorf, T.
Vogel, C. D. Pauza, R. E. Bontrop, R. DeMars, A.
Sette, A. L. Hughes, and D. I. Watkins. 1999.
Virus-specific cytotoxic T-lymphocyte responses select
for amino-acid variation in simian immunodeficiency
virus Env and Nef. Nat Med 5:1270.
One of the first pieces of definitive evidence of CTL
escape in SIV infection.
