Dave's Calendar
Dave's CV


It's mid-November. Madison is getting cold again and everyone is preparing for another long winter. The best part of seasons in Madison is that each one has a distinctive character. Most years, I feel like these long days of winter are among the most productive, while in the summer it is more relaxed as people spend time outside.

2015 has been very busy. Many senior staff have had the opportunity to make exciting career transitions. Matt Reynolds, a Scientist in the lab, received his own NIH R01 grant to explore alloimmunization as an HIV vaccine. Adam Bailey successfully defended his PhD thesis and returned to med school to complete his MD. Justin Greene accepted a scientist position at the Oregon Health and Sciences University working with longtime friend of the lab Jonah Sacha. Finally, after our lab visited Promega Corporation this summer to discuss possible collaborations Michael Lauck was sufficiently impressed with their work that he joined their team. While these transitions are difficult for our lab, I'm delighted to see members of the lab advance and succeed in their careers.

Though we've had personnel turnover, it has been a productive year. We recently published a review paper on simian arteriviruses. Earlier in the year, we described the first animal model for human pegivirus infection and recently received a new NIH R01 grant to further develop this model. Understanding cellular immunity to HIV/SIV remains a priority and we continue to study cellular adoptive transfers and define CD8+ and CD4+ T cell epitopes. We are also doing a lot of work with immunogenetics and genomics. With help from the Center for High Throughput Computing, we used thousands of CPUs to analyze whole genome and whole exome sequences from hundreds of macaques. Technologically, the biggest change in the year has been our adaptation of Pacific Biosciences deep sequencing to characterize full-length MHC, KIR, and FCGR transcripts. For the first time, we are able to catalog hundreds of novel allelic variants at these loci, which will hopefully improve out understanding about how variation in these genes influences infectious disease resistance.

If you are reading this in anticipation of applying to do PhD research at UW-Madison in 2016, I am most likely to take students with three or more years of independent funding because this allows students the greatest flexibility in developing a research project that matches their interests. I have had open PVLs for technicians and scientists throughout 2015, so if you are interested in joining our team with a BS or PhD, I encourage you to apply or contact me for additional information. I seek motivated, talented, creative, team-oriented individuals who are interested in conducting world-class infectious disease research.