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Site last updated 7/30/2003.

Matyas Sandor, Ph.D.

M. Sandor

Office: 5468 MSC
1300 University Ave.
Madison, WI 53706
Phone: 608-265-8715
Email: msandor@facstaff.wisc.edu

Pathology Department Site-Sandor

RESEARCH EMPHASIS:

The major focus of my laboratory is the study of immune responses to infectious diseases. We study the role of T cells in granulomatous immune responses induced by various infectious agents including Mycobacterium bovis. Granulomas are localized inflammatory reactions in which both T cells and the infectious agents are co-localized in the lesion. Granulomas are a hallmark of pathogenesis and a site of intense host-bacteria interaction. They protect the host against infection but can also cause diseases such as sarcoidosis or Crohn's disease. Using T cells from TCR transgenic mice as a source of monoclonal T cells of known antigen specificity and recombinant infectious agents expressing the antigenic epitopes recognized by the transgenic TCR, we examine how T cells fight chronic infections. We are interested in how different T cells work together in a local inflammatory site to control bacteria. Our experimental approach uses panels of genetically altered T cells and bacteria to identify important molecules and pathways required for granuloma formation. We also study how antibodies and antibody associated effector pathways mediated by complement and Fc receptors interfere with T cell responses. We hope our studies will contribute to the creation of better anti-bacterial vaccines and treatments for granulomatous diseases.

CURRICULUM VITAE

  • Education:

    1975; M.S. Biology; Eotvos L. Univ. of Science, Budapest, Hungary

    1979; Ph.D. Microbiology; Eotvos L. Univ. of Science, Budapest, Hungary

  • Research and Professional experience:

    1978-81; Postdoctoral Fellowship, Hungarian Academy of Sciences, Budapest, Hungary.

    1980-81; Fogarty Visiting Scientist Fellowship, Laboratory of Immunology, NCI, NIH, Bethesda, MD.

    1981-91; Associate Scientist, Dept. of Immunolgy, Eotvos L. University of Science, Budapest, Hungary.

    1984; Free Univ. Scholarship, Dept. of Clin. & Exp. Immunology, Free Univ., Berlin, W. Germany.

    1985; INSERM Scholarship, Laboratory of Cellular Immunology, Inst. Curie, Paris, France.

    1986-95; Visiting Scientist, Postdoctoral Associate, Res. Scientist; Dept, of Pathology, Univ. of Iowa.

    1995-01; Assistant Professor, Department of Pathology & Lab. Medicine, Univ. of Wisconsin-Madison.

    2001-present; Associate Professor, Department of Pathology & Lab. Medicine, Univ. of Wisconsin-Madison.

  • Societies:

    American Association of Immunologists

    International Association of Immunologists

    American Society of Tropical Medicine and Hygiene

    American Society for Investigative Pathology

    Infection and Immunity Editorial Board


RECENT PUBLICATIONS

  • Sewell, D.L., E.K. Reinke, D.O. Co, L.H. Hogan, R.B. Fritz, M. Sandor, and Z. Fabry. 2003. Infection with Mycobacterium bovis BCG diverts traffic of myelin oligodendroglial glycoprotein autoantigen-specific T Cells away from the central nervous system and ameliorates experimental autoimmune encephalomyelitis.Clin Diagn. Lab. Immunol. 10:564.

  • Sandor, M., J.V. Weinstock, and T.A. Wynn. 2003. Response to Doenhoff: Granulomas: these gizmos are cool! Trends Immunol. 24:169.

  • Swanson, B.J., D.C. Baiu, M. Sandor, Z. Fabry, and M.N. Hart. 2003. A small population of vasculitogenic T cells expands and has skewed T cell receptor usage after culture with syngeneic smooth muscle cells. J. Autoimmun. 20:125.

  • Fee, D, A. Crumbaugh, T. Jacques, B. Herdrich, D. Sewell, D. Auerbach, S. Piaskowski, M.N. Hart, M. Sandor, and Z. Fabry. 2003. Activated/effector CD4+ T cells exacerbate acute damage in the central nervous system following traumatic injury. J. Neuroimmunol. 136:54.

  • Sandor, M., J.V. Weinstock, and T.A. Wynn. 2003. Granulomas in schistosome and mycobacterial infections: a model of local immune responses. Trends in Immunol. 24:44.

  • Sewell, D., Z. Qing, E. Reinke, D. Elliot, J. Weinstock, M. Sandor, and Z. Fabry. 2003. Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization. Int. Immunol. 15:59.

  • Hofstetter, H.H., D.L. Sewell, F. Liu, M. Sandor, T. Forsthuber, P.V. Lehmann, and Z. Fabry. 2003. Autoreactive T cells promote post-traumatic healing in the central nervous system. J. Neuroimmunol. 134:25.

  • Suresh, M., H. Molina, M.S. Salvato, J.D. Mastellos, D. Lambris, and M. Sandor. 2003. Complement component 3 is required for optimal expansion of CD8 T cells during a systemic viral infection. J. Immunol. 170:788.

  • Hogan, L.H., M. Wang, M. Suresh, D.O. Co, J.V. Weinstock, and M. Sandor. 2002. CD4+ TCR repertoire heterogeneity in Schistosoma mansoni induced granulomas. J. Immunol. 169:6386.

  • Sewell, D.L., E.K. Reinke, L.H. Hogan, M. Sandor, and Z. Fabry. 2002. Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections. Immunol. Lett. 82:101.

  • Sacco, R., M. Hagen, M. Sandor, J. Weinstock, and R. Lynch. 2002. Established T(H1) Granulomatous Responses Induced by Active M.avium Infection Switch to T(H2) Following Challenge with S. mansoni. Clin. Immunol. 104:274.

  • Metwali, A., B. de Andres, A. Blum, D. Elliott, J. Li, K. Qadir, M. Sandor, and J. Weinstock. 2002. Th2-type granuloma development in acute murine schistosomiasis is only partly dependent on CD4+ T cells as the source of IL-4. Eur. J. Immunol. 32:1242.

  • Qing, Z., M. Sandor, Z. Radvany, D. Sewell, A. Folus, D. Potthof, W.A. Muller, and Z. Fabry. 2001. Inhibition of antigen-specific T cell trafficking into the cetnral nervous system via blocking PECAM/CD31 molecule. J. Neurol. Exp. Neuropathol. 60:798.

  • Hogan, L.H., W. Markofski, A. Bock, B. Barger, J.D. Morrissey, and M. Sandor. 2001. Mycobacterium bovis-BCG induced granuloma formation depends on gamma interferon and CD40 ligand but does not require CD28. Infect. Immun. 69:2596.

  • Hogan, L.H., K. Macvilay, B. Barger, D. Co, I. Malkovska, G. Fennelly, and M. Sandor. 2001. Mycobacterium bovis strain Calmette-Guérin bacillus-induced liver granulomas contain a diverse TCR repertoire, but a monoclonal T cell population is sufficient for protective granuloma formation. J. Immunol. 166:6367.

  • Radvany, Z., Z. Darvas, K. Kerekes, J. Prechl, C. Szalai, E. Pallinger, L. Valeria, V.L. Varga, M. Sandor, A. Erdei, and A. Falus. 2000. H1 histamine receptor antagonist inhibits constitutive growth of Jurkat T cells and antigen-specific proliferation of ovalbumin-specific murine T cells. Semin. Cancer Biol. 10:41.

  • Qing, Z., D. Sewell, M. Sandor, and Z. Fabry. 2000. Antigen-specific T cell trafficking into the central nervous system. J. Neuroimmunol. 105:169.

  • Fee, D., D. Grzybicki, M. Dobbs, S. Ihyer, J. Clotfelter, S. Macvilay, M.N. Hart, M. Sandor, and Z. Fabry. 2000. Interleukin 6 promotes vasculogenesis of murine brain microvessel endothelial cells. Cytokine 12:655.

  • Weinstock, J.V., D. Elliott, A. Metwali, A. Blum, J. Li, K. Qadir, and M. Sandor. 1999. Immunoregulation within the granulomas of murine schistosomiasis mansoni. Microbes. Infect. 1:491.

  • Weidanz, W.P., J.R. Kemp, J.M. Batchelder, F.K. Cigel, M. Sandor, and H.C. Heyde. 1999. Plasticity of immune responses suppressing parasitemia during acute Plasmodium chabaudi malaria. J. Immunol. 162:7383.