Web page designed and maintained by L.H.Hogan. Textures from Imagine and design elements from Windy's Design Studio Site last updated 7/14/2003.
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Zsuzsa Fabry, Ph.D. |
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The influx of T lymphocytes into the CNS is an important part of the immunopathology of various autoimmune and infectious diseases in the brain,such as Multiple Sclerosis (MS). My laboratory is using animal models to study this process. One of our goals is to interfere with autoimmune TH1-type T cells in the CNS by inhibiting their traffic across the blood-brain barrier or influencing their cytokine production. We also propose that activation of protective TH2-type immunity during the course of MS can lead to a remission phase in the disease.
A second focus of my laboratory is post-traumatic tissue regeneration in the brain. Tissue injury could happen as a result of autoimmune process or direct physical damage. Currently, we are characterizing new methods, involving the immune system, to accelerate tissue repair in the CNS.
Our ultimate goal is to design new treatments for Th1-type autoimmune diseases, such as MS.
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CURRICULUM VITAE
Education:
1984; Ph.D. Immunology; Eotvos L. Univ. of Science, Budapest, Hungary
Research and Professional experience:
1985; INSERM Scholarship, Laboratory of Cellular Immunology, Inst. Curie, Paris, France.
1986-95; Postdoctoral Associate, Department of Pathology, University of Iowa.
1993-95; Co-Director of Neuropathology Laboratory, University of Iowa.
1995-01; Assistant Professor, Dept of Pathology & Lab. Medicine, Univ. of Wisconsin-Madison.
2001-present; Associate Professor, Dept of Pathology & Lab. Medicine, Univ. of Wisconsin-Madison.
Societies:
American Association of Immunologists
International Association of Neuroimmunologists
American Association for the Advancement of Science
Society for Neuroscience
Journal of Neuropathology and Experimental Neurology Editorial Board
RECENT PUBLICATIONS
- Pachter J.S., H.E. de Vries, and Z. Fabry. 2003. The blood-brain barrier and its role in immune privilege in the central nervous system. J. Neuropathol. Exp. Neurol. 62:593.
- Sewell, D.L., E.K. Reinke, D.O. Co, L.H. Hogan, R.B. Fritz, M. Sandor, and Z. Fabry. 2003. Infection with Mycobacterium bovis BCG diverts traffic of myelin oligodendroglial glycoprotein autoantigen-specific T Cells away from the central nervous system and ameliorates experimental autoimmune encephalomyelitis. Clin. Diagn. Lab. Immunol. 10:564.
- Swanson, B.J., D.C. Baiu, M. Sandor, Z. Fabry, and M.N. Hart. 2003. A small population of vasculitogenic T cells expands and has skewed T cell receptor usage after culture with syngeneic smooth muscle cells. J. Autoimmun. 20:125.
- Fee, D, A. Crumbaugh, T. Jacques, B. Herdrich, D. Sewell, D. Auerbach, S. Piaskowski, M.N. Hart, M. Sandor, and Z. Fabry. 2003. Activated/effector CD4+ T cells exacerbate acute damage in the central nervous system following traumatic injury. J. Neuroimmunol. 136:54.
- Sewell, D., Z. Qing, E. Reinke, D. Elliot, J. Weinstock, M. Sandor, and Z.Fabry. 2003. Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization. Int. Immunol. 15:59.
- Hofstetter, H.H., D.L. Sewell, F. Liu, M. Sandor, T. Forsthuber, P.V. Lehmann, and Z. Fabry. 2003. Autoreactive T cells promote post-traumatic healing in the central nervous system. J. Neuroimmunol 134:25.
- Sewell, D.L., E.K. Reinke, L.H. Hogan, M. Sandor, and Z. Fabry. 2002. Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections. Immunol. Lett. 82:101.
- Qing, Z., M. Sandor, Z. Radvany, D. Sewell, A. Folus, D. Potthof, W.A. Muller, and Z. Fabry. 2001.
Inhibition of antigen-specific T cell trafficking into the cetnral nervous system via blocking
PECAM/CD31 molecule. J. Neurol. Exp. Neuropathol. 60:798.
- Swartz, K.R., F. Liu, D. Sewell, T. Schochet, I. Campbell, M. Sandor, and Z. Fabry. 2001.
Interleukin-6 promotes post-traumatic healing in the central nervous system. Brain Res. 896:86.
- Qing, Z., D. Sewell, M. Sandor, and Z. Fabry. 2000. Antigen-specific T cell trafficking into the
central nervous system. J. Neuroimmunol. 105:169.
- Fee, D., D. Grzybicki, M. Dobbs, S. Ihyer, J. Clotfelter, S. Macvilay, M. N. Hart, M. Sandor, and Z. Fabry. 2000. Interleukin 6 promotes vasculogenesis of murine brain microvessel endothelial cells. Cytokine 12:655.
- Blum, A.M., A. Metwali, M. Kim-Miller, J. Li, K. Qadir, D.E. Elliott, B. Lu, Z. Fabry, N. Gerard, and J.V. Weinstock. 1999. The substance P receptor is necessary for a normal granulomatous response in murine schistosomiasis mansoni. J. Immunol. 162:6080.
- Reyes, T.M., Z. Fabry, and C.L. Coe. 1999. Brain endothelial cell production of a neuroprotective cytokine, interleukin-6,in response to noxious stimuli. Brain Res. 851:215.
- Karassin, A., B. Macvilay, M.N. Hart, and Z. Fabry. 1998. Murine endothelia do not express MHC class II I-Ea subunit and differentially regulate I-Aa expression along the vascular tree. Endothelium. 6:83.
- Brayton, J., Z. Quing, J.C. VanGilder, M.N. Hart, and Z. Fabry. 1998. Influence of adhesion molecule expression by human brain microvessel endothelium on cancer cell adhesion.
J. Neuroimmun.89:104.
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